Parallelized engineering of mutational models using piggyBac transposon delivery of CRISPR libraries

Xander Nuttle, Nicholas D. Burt, Benjamin Currall, Mariana Moysés-Oliveira, Kiana Mohajeri, Riya Bhavsar, Diane Lucente, Rachita Yadav, Derek J.C. Tai, James F. Gusella, Michael E. Talkowski

Cell Reports Methods 2024

Convergent coexpression of autism-associated genes suggests some novel risk genes may not be detectable in large-scale genetic studies

Calwing Liao, Mariana Moyses-Oliveira, Celine E.F. de Esch, Riya Bhavsar, Xander Nuttle, Aiqun Li, Alex Yu, Nicholas D. Burt, Serkan Erdin, Jack M. Fu, Minghui Wang, Theodore Morley, Lide Han, CommonMind Consortium, Patrick A. Dion, Guy A. Rouleau, Bin Zhang, Kristen J. Brennand, Michael E. Talkowski, Douglas M. Ruderfer

Cell Genomics 2023

Tissue- and cell-type-specific molecular and functional signatures of 16p11.2 reciprocal genomic disorder across mouse brain and human neuronal models

Derek J.C. Tai, Parisa Razaz, Serkan Erdin, Dadi Gao, Jennifer Wang, Xander Nuttle, Celine E. de Esch, Ryan L. Collins, Benjamin B. Currall, Kathryn O’Keefe, Nicholas D. Burt, Rachita Yadav, Lily Wang, Kiana Mohajeri, Tatsiana Aneichyk, Ashok Ragavendran, Alexei Stortchevoi, Elisabetta Morini, Weiyuan Ma, Diane Lucente, Alex Hastie, Raymond J. Kelleher, Roy H. Perlis, Michael E. Talkowski, James F. Gusella

American Journal of Human Genetics 2022

Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility

Xander Nuttle, Giuliana Giannuzzi, Michael H. Duyzend, Joshua G. Schraiber, Iñigo Narvaiza, Peter H. Sudmant, Osnat Penn, Giorgia Chiatante, Maika Malig, John Huddleston, Chris Benner, Francesca Camponeschi, Simone Ciofi-Baffoni, Holly A. F. Stessman, Maria C. N. Marchetto, Laura Denman, Lana Harshman, Carl Baker, Archana Raja, Kelsi Penewit, Nicolette Janke, W. Joyce Tang, Mario Ventura, Lucia Banci, Francesca Antonacci, Joshua M. Akey, Chris T. Amemiya, Fred H. Gage, Alexandre Reymond, Evan E. Eichler

Nature 2016

Rapid and accurate large-scale genotyping of duplicated genes and discovery of interlocus gene conversions

Xander Nuttle, John Huddleston, Brian J. O'Roak, Francesca Antonacci, Marco Fichera, Corrado Romano, Jay Shendure, Evan E. Eichler

Nature Methods 2013

Evolution of Human-Specific Neural SRGAP2 Genes by Incomplete Segmental Duplication

Megan Y. Dennis, Xander Nuttle, Peter H. Sudmant, Francesca Antonacci, Tina A. Graves, Mikhail Nefedov, Jill A. Rosenfeld, Saba Sajjadian, Maika Malig, Holland Kotkiewicz, Cynthia J. Curry, Susan Shafer, Lisa G. Shaffer, Pieter J. de Jong, Richard K. Wilson, Evan E. Eichler

Cell 2012